Ammonia → (4-{4-[2-(Carbamoylmethylamino)ethoxy]phenyl}butyl)carbamic acid tert-butyl ester

HRID 1890804Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1890804
C(O[C:4](=[O:28])[CH2:5][NH:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])=[CH:12][CH:11]=1)C.[NH3:29]>>[C:24]([O:23][C:21](=[O:22])[NH:20][CH2:19][CH2:18][CH2:17][CH2:16][C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:8][CH2:7][NH:6][CH2:5][C:4](=[O:28])[NH2:29])=[CH:15][CH:14]=1)([CH3:25])([CH3:26])[CH3:27]

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 58809798{2-[4-(4-tert-Butoxycarbonylaminobutyl)phenoxy]ethylamino}acetic acid ethyl ester

Produkt 1

HCID 58809802(4-{4-[2-(Carbamoylmethylamino)ethoxy]phenyl}butyl)carbamic acid tert-butyl ester

Versuchsvorschrift

A solution of 2 (0.27 g, 0.685 mmol) dissolved in 7 N methanolic ammonia (25 mL) was stirred in a sealed tube at room temperature overnight. After this time, TLC analysis indicated that the reaction was complete. The reaction mixture was concentrated and further dried under vacuum to afford the desired product 3 (0.25 g, quantitative yield) as a yellow viscous oil which was used directly without further purification. m/z (ESI) 366.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. customfurther dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-765619b5aa6042f2bf5f3de22005d88a
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08507497B2

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