N,N-dimethyl-1-(3-nitrophenyl)methanesulfonamide → 1-(3-aminophenyl)-N,N-dimethylmethanesulfonamide

HRID 1890976Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1890976
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][S:11]([N:14]([CH3:16])[CH3:15])(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=1)([O-])=O>[Ni].CO>[NH2:1][C:4]1[CH:5]=[C:6]([CH2:10][S:11]([N:14]([CH3:16])[CH3:15])(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 1

HCID 28632733N,N-dimethyl-1-(3-nitrophenyl)methanesulfonamide

Produkt 1

HCID 432562151-(3-aminophenyl)-N,N-dimethylmethanesulfonamideAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

(3-nitrophenyl)-N,N-dimethylmethanesulfonamide (2.32 g, 9.5 mmol) was hydrogenated over Raney nickel (0.5 g) in methanol at 50° C. and 70 psi for 4 h, then catalyst was filtered off, washed with warm methanol, combined filtrates were evaporated to give 1.95 g (96%) of (3-aminophenyl)-N,N-dimethylmethanesulfonamide.

Aufarbeitung

  1. filtrationcatalyst was filtered off
  2. washwashed with warm methanol
  3. customwere evaporated

Quellen und Nachweise

ORD-Eintrag
ord-95216d08bd9a4a8a8340c3376e4a882b
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08507498B2

Notizen zur Reaktion

Wird geladen…