Hydrochloric Acid → {3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol hydrochloride

HRID 1891240Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1891240
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[C:19]([CH2:23][OH:24])[CH:20]=[CH:21][CH:22]=3)=[CH:13][N:12]2[C:25]=1[CH3:26].[ClH:27]>ClCCl.CO.C(O)(C)C>[ClH:27].[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:10]=[C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:18]=[C:19]([CH2:23][OH:24])[CH:20]=[CH:21][CH:22]=3)=[CH:13][N:12]2[C:25]=1[CH3:26]

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 44233767{3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol

Produkt 1

HCID 44233766{3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 3776IsopropanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A solution of 130 mg of {3-[2-(2,4-difluorophenyl)-3-methylimidazo[1,2-α]pyridin-6-yl]phenyl}methanol in dichloromethane and methanol is passed through a frit and 3.7 ml of a 0.1N solution of hydrochloric acid in isopropanol are added to the filtrate. The reaction mixture is then concentrated under reduced pressure. The residue obtained is triturated from diethyl ether and recovered by filtration and then oven-dried under reduced pressure. 128 mg of compound are obtained.

Aufarbeitung

  1. additionare added to the filtrate
  2. concentrationThe reaction mixture is then concentrated under reduced pressure
  3. customThe residue obtained
  4. customis triturated from diethyl ether
  5. filtrationrecovered by filtration
  6. customoven-dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-aab69326ba28499b866b5beeba3ca10a
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08507520B2

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