N-(4-Formyl-1,3-thiazol-2-YL)acetamide → HCID 86762009, Verbindung
Reaktionsgleichung
[CH:1]([C:3]1[N:4]=[C:5]([NH:8][C:9](=[O:11])[CH3:10])[S:6][CH:7]=1)=O.[Br-].[C:13]([C:16]1[CH:17]=[C:18]([CH:39]=[CH:40][CH:41]=1)[CH2:19][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([OH:15])=[O:14]>>[C:9]([NH:8][C:5]1[S:6][CH:7]=[C:3]([CH:1]=[CH:19][C:18]2[CH:17]=[C:16]([CH:41]=[CH:40][CH:39]=2)[C:13]([OH:15])=[O:14])[N:4]=1)(=[O:11])[CH3:10]Komponenten
3
Versuchsvorschrift
N-(4-Formyl-1,3-thiazol-2-yl)acetamide (1.702 g, 10.00 mmol) and (3-carboxybenzyl)(triphenyl)phosphonium bromide (5.251 g, 11.00 mmol) were condensed by a method similar to that of Production Example 4, step 3, to give 3-{2-[2-(acetylamino)-1,3-thiazol-4-yl]vinyl}benzoic acid (2.862 g, 9.926 mmol, yield 99.3%) as a pale-yellow solid.
Aufarbeitung
- customcondensed by a method similar to that of Production Example 4, step 3