CID 6037 → N,N'-Dicyclohexylurea

HRID 1893086

Reaktionsgleichung

Reaktionsgleichung von HRID 1893086
C1C(C(N[C@H](C(O)=O)CCC(O)=O)=[O:8])=CC=C(NCC2N=C3C(N=C(N)NC3=NC=2)=O)C=1.[CH2:33]1[CH2:38][CH2:37][CH:36]([N:39]=[C:40]=[N:41][CH:42]2[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]2)[CH2:35][CH2:34]1>CS(C)=O>[C:40]([NH:39][CH:36]1[CH2:35][CH2:34][CH2:33][CH2:38][CH2:37]1)([NH:41][CH:42]1[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]1)=[O:8]

Komponenten

4

Edukt 2

HCID 6037CID 6037HCID 10868Dicyclohexylcarbodiimide

Produkt 1

HCID 4277N,N'-Dicyclohexylurea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

The carboxylic acid group of folic add (1.0 g, 2 mmol) dissolved in 20 mL of DMSO was pre-activated with DCC (0.495 g, 2.4 mmol) and NHS (0.463 g 4 mmol) at room temperature (Scheme 2). In the reaction, dicyclohexylurea was formed and removed by filtration. The vacuum-dried precursor polymer was added to the reaction solution. The reaction was kept at room temperature for 48 hours. The resulting solution was placed in a dialysis membrane with a molecular weight cut-off of 2000 and dialyzed against DI water for one week. The final product was harvested by freeze-drying.

Aufarbeitung

  1. customIn the reaction

Quellen und Nachweise

ORD-Eintrag
ord-1d0f465130cd425f9118beddab22a673
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08512757B2

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