Reaktionsgleichung
[C:1]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[N:12]([C:32]([N:34]3[CH2:39][C@@H:38]4[C@@H:36]([CH:37]4[C:40]([OH:42])=O)[CH2:35]3)=[O:33])[C@@:13]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)([CH3:24])[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=2)=[C:7]([O:43][CH2:44][CH3:45])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH2:46][CH2:47][CH2:48][OH:49]>>[OH:49][CH2:48][CH2:47][NH:46][C:40]([CH:37]1[C@@H:36]2[C@H:38]1[CH2:39][N:34]([C:32]([N:12]1[C@@:13]([C:25]3[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=3)([CH3:24])[C@@:14]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)([CH3:16])[N:15]=[C:11]1[C:8]1[CH:9]=[N:10][C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])=[CH:6][C:7]=1[O:43][CH2:44][CH3:45])=[O:33])[CH2:35]2)=[O:42]Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
In a manner analogous to the method described in examples 99, (1S,5R)-3-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid (prepared from the ethyl ester, example 135) was coupled with 2-aminoethanol (Aldrich) to give the title compound. HR-MS (ES, m/z) calculated for C37H44Cl2N5O4 [(M+H)+] 692.2765, observed 692.2768.
Quellen und Nachweise
- ORD-Eintrag
- ord-6bc48671936c44c8942892019eb7cd6d
- Quelldatensatz
- uspto-grants-2013_08
- Patentnummer
- US08513239B2
Verknüpfte Notizen
Wird geladen…