Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | (Z)-2-Hydroxy Doxepin | HCID 67319009 | — |
| Lösungsmittel | Hydrochloric Acid | HCID 313 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | (E)-2-Hydroxy Doxepin | HCID 59023617 | — |
Reaktionsschritte
A mixture of (Z)-2-Hydroxy-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenzo[b,e]oxepin (2.5 mg, 8.5×10−6 mol) was dissolved in a mixture of hydrochloric acid (1 mL) and methanol (9 mL) and heated at 140° C. (oil bath) for 4 hr. The product was isolated by means of HPLC and evaporation of solvents.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US08513299B2 |
|---|
| Quelldatensatz | uspto-grants-2013_08 |
|---|
| ORD ID | ord-d7316b5332224b23afe943ea57d90c92 |
|---|
| Quellennotiz | uspto-grants-2013_08 |
|---|
