Tetrahydrofuran → 2-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid

HRID 1895389Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1895389
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[S:9][CH:10]=1)=[O:5])C.O1CCCC1.[OH-].[Na+]>CO>[N:15]1[CH:16]=[CH:17][C:12]([NH:11][C:8]2[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)=[CH:13][CH:14]=1

Komponenten

5

Edukt 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 27420752-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid ethyl ester

Produkt 1

HCID 181867402-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid (160 mg) was prepared according to General Procedure C using 2-(pyridin-4-ylamino)-thiazole-4-carboxylic acid ethyl ester in methanol:tetrahydrofuran:2N NaOH (1:1:1, 1.5 mL). The solvents were evaporated and the compound was dried. The crude product was used without further purification.

Aufarbeitung

  1. customThe solvents were evaporated
  2. customthe compound was dried
  3. customThe crude product was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-8a86c1ceea4c4d9b870e0da0a508ccf4
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08513430B2

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