Benzene, 2-fluoro-4-methyl-1-nitro- → 2-Methyl-6-{3-[1-(5-methyl-2-nitrophenyl)piperidin-4-ylidene]prop-1-ynyl}pyridine

Beteiligte Stoffe

Reaktionsschritte

A well homogenised mixture of the Compound of Example 3 (19 mg, 0.89 mmol) and 3-fluoro-4-nitrotoluene (20.2 mg, 0.13 mmol) was stirred at 120° C. for 0.5 h. The reaction crude was purified by flash chromatography (EtOAc—Petroleum Ether gradient from 2:8 to 3:7) affording the title product (18 mg).

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