Tert-butyl 4-[3-(5-cyanopyridin-3-yl)prop-2-ynylidene]piperidine-1-carboxylate → 5-(3-Piperidin-4-ylideneprop-1-ynyl)pyridine-2-carbonitrile

HRID 1895968

Reaktionsgleichung

Reaktionsgleichung von HRID 1895968
C[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]#[C:9][CH:10]=[C:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[N:3]=1.[C:17](C1C=C(C#CC=C2CCN(C(OC(C)(C)C)=O)CC2)C=NC=1)#[N:18]>>[NH:14]1[CH2:13][CH2:12][C:11](=[CH:10][C:9]#[C:8][C:4]2[CH:5]=[CH:6][C:7]([C:2]#[N:3])=[N:18][CH:17]=2)[CH2:16][CH2:15]1

Komponenten

3

Edukt 2

HCID 25183829Tert-butyl 4-[3-(5-cyanopyridin-3-yl)prop-2-ynylidene]piperidine-1-carboxylateHCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

Produkt 1

HCID 875497035-(3-Piperidin-4-ylideneprop-1-ynyl)pyridine-2-carbonitrile

Versuchsvorschrift

The title compounds were prepared following the procedure described for the compound of Example 3 but starting respectively from the compounds of Example 45 and 46 instead of the compound of Example 2. The crudes were used in the next step without further purification.

Aufarbeitung

  1. customThe crudes were used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-77ce2b0e472a4b3587e90754b2777946
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08518916B2

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