Tert-butyl 4-[1-hydroxy-3-(6-methylpyridin-2-yl)prop-2-ynyl]piperidine-1-carboxylate → 3-(6-Methyl-pyridin-2-yl)-1-piperidin-4-yl-prop-2-yn-1-ol

HRID 1895992Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1895992
CC1C=CC=C(C#CC=C2CCNCC2)N=1.[OH:17][CH:18]([CH:28]1[CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29]1)[C:19]#[C:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH3:27])[N:22]=1>>[CH3:27][C:23]1[N:22]=[C:21]([C:20]#[C:19][CH:18]([CH:28]2[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]2)[OH:17])[CH:26]=[CH:25][CH:24]=1

Komponenten

3

Edukt 2

HCID 68725592Tert-butyl 4-[1-hydroxy-3-(6-methylpyridin-2-yl)prop-2-ynyl]piperidine-1-carboxylateHCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

Produkt 1

HCID 689774953-(6-Methyl-pyridin-2-yl)-1-piperidin-4-yl-prop-2-yn-1-ol

Versuchsvorschrift

The title compound was prepared following the procedure described for the compound of Example 3, using the Compound of Example 39 instead of the Compound of Example 2. After the usual work-up procedure, the crude was used in the next step without further purification.

Aufarbeitung

  1. customAfter the usual work-up procedure, the crude was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-4517455cfc04487fa2d27d7eb5470dec
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08518916B2

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