Tert-butyl 4-[3-(3,5-difluorophenyl)prop-2-yn-1-yl]piperidine-1-carboxylate → 4-[3-(3,5-Difluorophenyl)prop-2-ynyl]piperidine

HRID 1895999Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1895999
CC1C=CC=C(C#CC=C2CCNCC2)N=1.[F:17][C:18]1[CH:19]=[C:20]([C:25]#[C:26][CH2:27][CH:28]2[CH2:33][CH2:32][N:31](C(OC(C)(C)C)=O)[CH2:30][CH2:29]2)[CH:21]=[C:22]([F:24])[CH:23]=1>>[F:17][C:18]1[CH:19]=[C:20]([C:25]#[C:26][CH2:27][CH:28]2[CH2:29][CH2:30][NH:31][CH2:32][CH2:33]2)[CH:21]=[C:22]([F:24])[CH:23]=1

Komponenten

3

Edukt 2

HCID 68726123Tert-butyl 4-[3-(3,5-difluorophenyl)prop-2-yn-1-yl]piperidine-1-carboxylateHCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

Produkt 1

HCID 689794914-[3-(3,5-Difluorophenyl)prop-2-ynyl]piperidine

Versuchsvorschrift

The title compound was prepared following the procedure described for the Compound of Example 3, using the Compound of Example 247 instead of the Compound of Example 2. After the usual work-up procedure, the crude was used for the next step without further purification.

Aufarbeitung

  1. customAfter the usual work-up procedure, the crude was used for the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-76778855337f410894fdcfa7854d8862
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08518916B2

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