2-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine → 2-Bromo-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

HRID 1896035Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1896035
CC1C=CC=C(C#CC=C2CCNCC2)N=1.[Br:17][C:18]1[N:23]=[C:22]([C:24]#[C:25][CH:26]=[C:27]2[CH2:32][CH2:31][N:30](C(OC(C)(C)C)=O)[CH2:29][CH2:28]2)[CH:21]=[CH:20][CH:19]=1>>[Br:17][C:18]1[CH:19]=[CH:20][CH:21]=[C:22]([C:24]#[C:25][CH:26]=[C:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[N:23]=1

Komponenten

3

Edukt 2

HCID 875504022-Methyl-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridineHCID 87641844Tert-butyl 4-[3-(6-bromopyridin-2-yl)prop-2-ynylidene]piperidine-1-carboxylate

Produkt 1

HCID 876422122-Bromo-6-(3-piperidin-4-ylideneprop-1-ynyl)pyridine

Versuchsvorschrift

The title product was prepared following the method described for the Compound of Example 3 but using as starting material Compound 305a instead of the Compound of Example 2 and stirring at ambient temperature for 3 days. The reaction mixture was evaporated to dryness in vacuo, taking up the residue several times with chloroform to remove excess trifluoroacetic acid.

Aufarbeitung

  1. customThe reaction mixture was evaporated to dryness in vacuo
  2. customto remove excess trifluoroacetic acid

Quellen und Nachweise

ORD-Eintrag
ord-213125f6597a4d6fa6d15b244e585472
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08518916B2

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