Adenine → 9-(3-chloropropyl)-9H-purin-6-amine
Reaktionsgleichung
[N:1]1[C:9]([NH2:10])=[C:8]2[C:4]([N:5]=[CH:6][NH:7]2)=[N:3][CH:2]=1.Br[CH2:12][CH2:13][CH2:14][Cl:15].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:15][CH2:14][CH2:13][CH2:12][N:5]1[CH:6]=[N:7][C:8]2[C:4]1=[N:3][CH:2]=[N:1][C:9]=2[NH2:10]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of adenine (4.05 g, 30 mM), 1-bromo-3-chloropropane (21.3 g, 13.4 mM), and potassium carbonate (10.4 g, 75 mM) in DMF (200 mL) was stirred at room temperature under argon for 4 days, filtrated, and evaporated to dryness. The crude product was washed with water and dried. Recrystallization from ethanol gave 9-(3-chloropropyl)adenine in 59% yield.
Aufarbeitung
- filtrationfiltrated
- customevaporated to dryness
- washThe crude product was washed with water
- customdried
- customRecrystallization from ethanol
Quellen und Nachweise
- ORD-Eintrag
- ord-e475fa1b02de4f09940ae50d54b7dd4a
- Quelldatensatz
- uspto-grants-2013_08
- Patentnummer
- US08518885B2
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