Ethyl Acetate → HCID 45118147, Verbindung

HRID 1896785Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1896785
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH2:11])[CH:9]=2)[CH:4]=[CH:3]1.[C:12](Cl)(=[O:16])[CH:13]([CH3:15])[CH3:14].C(OCC)(=O)C>N1C=CC=CC=1>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([NH:11][C:12](=[O:16])[CH:13]([CH3:15])[CH3:14])[CH:9]=2)[CH:4]=[CH:3]1

Komponenten

5

Edukt 3

HCID 8857Ethyl AcetateHCID 62325Isobutyryl chlorideHCID 105347991-methyl-1H-indol-6-amine

Produkt 1

HCID 45118147HCID 45118147, VerbindungAusbeute 36,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a solution of 1-methyl-1H-indol-6-amine (45 mg, 0.31 mmol) in pyridine (2 mL) at room temperature was added isobutyryl chloride (35 μL, 0.34 mmol). The resulting mixture was stirred at room temperature for 16 h. Ethyl acetate was added and the organic layer was washed three times with brine. The combined organic layers were dried over anhydrous MgSO4 and evaporated to afford 24.3 mg (36%) of the title compound (LCMS RT=5.73 min, MH+ 217.2)

Aufarbeitung

  1. washthe organic layer was washed three times with brine
  2. dry with materialThe combined organic layers were dried over anhydrous MgSO4
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-3c408687a2b749529afbb1733d0bc22b
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08518980B2

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