4-Aminotetrahydropyran → 6-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide

HRID 1897358Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1897358
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:11]([CH2:12][O:13][C:14]2[CH:22]=[CH:21][C:17]([C:18]([OH:20])=O)=[CH:16][N:15]=2)=[CH:10][O:9][N:8]=1.[NH2:23][CH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[C:11]([CH2:12][O:13][C:14]2[CH:22]=[CH:21][C:17]([C:18]([NH:23][CH:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)=[O:20])=[CH:16][N:15]=2)=[CH:10][O:9][N:8]=1

Komponenten

3

Edukt 2

HCID 4192234-AminotetrahydropyranHCID 684452576-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid

Produkt 1

HCID 684427026-(3-Pyridin-2-yl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamideAusbeute 99 %

Versuchsvorschrift

As described for example 162b, 6-(3-pyridin-2-yl-isoxazol-4-ylmethoxy)-nicotinic acid (70 mg, 0.24 mmol) was converted using 4-aminotetrahydropyran instead of ethanolamine to the title compound (SiO2, heptane:ethyl acetate=50:50 to 0:100, 89 mg, 99%) which was obtained as a white solid. MS: m/e=381.5 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-48e53caad78a4d6f8d985859c31c7fe1
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08518974B2

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