Thionyl Chloride → 6-Fluoro-2-naphthoyl chloride

HRID 1897577

Reaktionsgleichung

Reaktionsgleichung von HRID 1897577
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([OH:14])=O)[CH:6]=[CH:5]2.S(Cl)([Cl:17])=O>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([Cl:17])=[O:14])[CH:6]=[CH:5]2

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 27827886-Fluoro-2-naphthoic acid

Produkt 1

HCID 866748346-Fluoro-2-naphthoyl chloride

Versuchsvorschrift

6-fluoro-2-naphthoic acid (2 g, 10.52 mmol) was stirred in thionyl chloride (21.03 ml) at 80° C. for 4 h in pressure vessel. The mixture was cooled and concentrated. The acid chloride was dried and used as is for next step.

Aufarbeitung

  1. temperatureThe mixture was cooled
  2. concentrationconcentrated
  3. dry with materialThe acid chloride was dried

Quellen und Nachweise

ORD-Eintrag
ord-9bce67345cf24d389ebf4192955b9154
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08519134B2

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