Sodium Hydroxide → HCID 178425067, Verbindung

HRID 1898309

Reaktionsgleichung

Reaktionsgleichung von HRID 1898309
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10]1[NH:11][C:12]2[C:18]3[CH2:19][C:20]([CH3:23])([CH3:22])[O:21][C:17]=3[C:16]([C:24]([O:26]C)=[O:25])=[CH:15][C:13]=2[N:14]=1.[OH-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10]1[NH:11][C:12]2[C:18]3[CH2:19][C:20]([CH3:23])([CH3:22])[O:21][C:17]=3[C:16]([C:24]([OH:26])=[O:25])=[CH:15][C:13]=2[N:14]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 178496983HCID 178496983, Verbindung

Produkt 1

HCID 178425067HCID 178425067, VerbindungAusbeute 83,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The title compound was prepared by following the procedure described for Step-2 of Intermediate-3 using methyl 2-[(2-chloro-6-methylphenyl)amino]-7,7-dimethyl-7,8-dihydro-1H-furo[3,2-e]benzimidazole-5-carboxylate (0.500 g, 1.29 mmol), methanol (1.0 mL) and (50%) aqueous solution of sodium hydroxide (0.500 g, 12.50 mmol) to afford 0.400 g of the desired product. 1HNMR (DMSO-d6): δ 1.40 (s, 6H), 2.21 (s, 3H), 2.94 (s, 2H), 7.18-7.34 (m, 4H), 11.0-12.00 (s, 3H), 12-13.00 (s, 1H); MS [M+H]+: 372.34.

Aufarbeitung

  1. customThe title compound was prepared

Quellen und Nachweise

ORD-Eintrag
ord-d6c9161a03d84ca7931e7abbbe0da97d
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08519149B2

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