Trifluoroacetic acid → 3-Methylazetidine-3-carbonitrile; trifluoroacetic acid

HRID 1898507Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1898507
C(OC([N:8]1[CH2:11][C:10]([C:13]#[N:14])([CH3:12])[CH2:9]1)=O)(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[C:13]([C:10]1([CH3:12])[CH2:11][NH:8][CH2:9]1)#[N:14]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 56971684tert-Butyl 3-cyano-3-methylazetidine-1-carboxylate

Produkt 1

HCID 673862343-Methylazetidine-3-carbonitrile; trifluoroacetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3-Cyano-3-methyl-azetidine-1-carboxylic acid tert-butyl ester (0.23 g, 1.17 mmol) was dissolved in 12 mL of dichloromethane and the reaction was then stirred in an ice bath. Trifluoroacetic acid (3.6 mL) was added slowly and the solution was warmed to room temperature. After 3 h the reaction mixture was evaporated to afford 3-cyano-3-methyl-azetidine trifluoroacetate which was used without further purification.

Aufarbeitung

  1. customAfter 3 h the reaction mixture was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-45e78b1486e74e1face942ff5f37f8b0
Quelldatensatz
uspto-grants-2013_08
Patentnummer
US08518945B2

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