Methyl iodide → 2-Chloro-1-methoxy-3-methyl-4-nitrobenzene

HRID 1898991Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1898991
[Cl:1][C:2]1[C:7]([CH3:8])=[C:6]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:4][C:3]=1[OH:12].[H-].[Na+].[CH3:15]I>CN(C=O)C>[Cl:1][C:2]1[C:7]([CH3:8])=[C:6]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:4][C:3]=1[O:12][CH3:15]

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 131473552-Chloro-3-methyl-4-nitrophenol

Produkt 1

HCID 137023832-Chloro-1-methoxy-3-methyl-4-nitrobenzeneAusbeute 81,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2-Chloro-3-methyl-4-nitrophenol (9.39 g, 50.0 mmol) was reacted with sodium hydride (50%, 2.64 g, 55.0 mmol) and methyl iodide (7.81 g, 55.0 mmol) in dry DMF (200 ml) by the method described in 1 (a). After treatment with water, the product was extracted with chloroform, and the dried extract evaporated to dryness, leaving an oil which crystallised on cooling, leaving solid 2-chloro-3-methyl-4-nitroanisole (8.19 g).

Aufarbeitung

  1. extractionAfter treatment with water, the product was extracted with chloroform
  2. extractionthe dried extract
  3. customevaporated to dryness
  4. customleaving an oil which
  5. customcrystallised
  6. temperatureon cooling

Quellen und Nachweise

ORD-Eintrag
ord-7a595a9bb28245488bfb0cabff633f57
Quelldatensatz
uspto-grants-1996_11
Patentnummer
US05571833

Notizen zur Reaktion

Wird geladen…