Fumaric Acid → HCID 67623235, Verbindung

HRID 1899835Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1899835
[CH2:1]([CH:8]1[O:12][C:11](=[O:13])[N:10]([CH2:14][CH2:15][CH:16]([N:23]2[CH2:28][CH2:27][O:26][CH2:25][CH2:24]2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33]>C(O)C>[C:29]([OH:36])(=[O:35])/[CH:30]=[CH:31]/[C:32]([OH:34])=[O:33].[CH2:1]([CH:8]1[O:12][C:11](=[O:13])[N:10]([CH2:14][CH2:15][CH:16]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 444972Fumaric AcidHCID 545585415-Benzyl-3-[3-(morpholin-4-yl)-3-phenylpropyl]-1,3-oxazolidin-2-one

Produkt 1

HCID 67623235HCID 67623235, VerbindungAusbeute 100,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

5-benzyl-3-(3-morpholino-3-phenylpropyl)-1,3-oxazolidin-2-one (0.26 g, 0.68 mmol) prepared in the same manner as is described in Example 9 and fumaric acid (0.08 g, 0.68 mmol) were dissolved in ethanol. From the resulting solution, ethanol was removed by distillation under reduced pressure. Water was added to the residue and then the resulting solution was concentrated. After the concentration was repeated for three times, the residue was dried in vacuum to obtain 0.34 g of the titled compound as a pale scarlet amorphous product (yield: 100%).

Aufarbeitung

  1. customFrom the resulting solution, ethanol was removed by distillation under reduced pressure
  2. additionWater was added to the residue
  3. concentrationthe resulting solution was concentrated
  4. concentrationAfter the concentration
  5. customthe residue was dried in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-b23d4cc7af3a4edfa89c0ca1e7942988
Quelldatensatz
uspto-grants-1996_11
Patentnummer
US05574030

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