HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Benzene → 2-[2-(4-Methoxycarbonylmethylphenoxy)-1-methylethyl]amino-1-(3-fluorophenyl)ethanol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Benzene | HCID 241 | — |
| Edukt | 2-Amino-1-(3-fluorophenyl)ethan-1-ol | HCID 35800 | — |
| Edukt | Sodium cyanoborohydride | HCID 5003444 | — |
| Edukt | Methyl 4-(2-oxopropoxy)phenylacetate | HCID 21832178 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 2-[2-(4-Methoxycarbonylmethylphenoxy)-1-methylethyl]amino-1-(3-fluorophenyl)ethanol | HCID 54320578 | 25,3% |
Reaktionsschritte
Following a procedure similar to that described in Example 6, but using 2 g of 2-amino-1-(3-fluorophenyl)ethanol (prepared as described in Preparation 13), 3.44 g of methyl 4-(2-oxopropoxy)phenylacetate (prepared as described in Preparation 3), 60 ml of benzene, 60 ml of absolute methanol and 3.6 g of sodium cyanoborohydride, 1.18 g of the title compound were obtained as crystals, melting at 52° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05576340 |
| Quelldatensatz | uspto-grants-1996_11 |
| ORD ID | ord-aae3d29f21e9493ca5b548da8b7b0d9a |
| Quellennotiz | uspto-grants-1996_11 |