1,1,1-Trifluoro-2-isothiocyanatoethane → HCID 178485065, Verbindung

HRID 1902259

Reaktionsgleichung

Reaktionsgleichung von HRID 1902259
[F:1][C:2]([F:8])([F:7])[CH2:3][N:4]=[C:5]=[S:6].[NH2:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][S:16][CH2:17][CH2:18][NH:19][C:20]([NH:24][CH3:25])=[N:21][C:22]#[N:23])[N:14]=1>CN(C)C=O>[F:1][C:2]([F:8])([F:7])[CH2:3][NH:4][C:5](=[S:6])[NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][S:16][CH2:17][CH2:18][NH:19][C:20]([NH:24][CH3:25])=[N:21][C:22]#[N:23])[N:14]=1

Komponenten

4

Edukt 2

HCID 138837771,1,1-Trifluoro-2-isothiocyanatoethaneHCID 178485066HCID 178485066, Verbindung

Produkt 1

HCID 178485065HCID 178485065, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 2,2,2-trifluoroethyl isothiocyanate (0.68 g.) and 2-amino-4-[2-(2-cyano-3-methylguanidino)-ethylthiomethyl]thiazole (1.08 g.) in dimethylformamide (5 ml.) was maintained at 60° for 4 hours and then evaporated to dryness. The residue was recrystallised from acetonitrile to give 2-[3-(2,2,2-trifluoroethyl)thioureido]-4-[2-(2-cyano-3-methylguanidino)ethylthiomethyl]thiazole, m.p. 157°-158°.

Aufarbeitung

  1. temperaturewas maintained at 60° for 4 hours
  2. customevaporated to dryness
  3. customThe residue was recrystallised from acetonitrile

Quellen und Nachweise

ORD-Eintrag
ord-e2a8844fae4c4b85b9e74d4df99d72be
Quelldatensatz
uspto-grants-1982_12
Patentnummer
US04362728

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