Methyl p-toluenesulfonate → 2-Fluoro-1-methylpyridinium p-toluenesulfonate

Beteiligte Stoffe

Reaktionsschritte

2-fluoro-1-methylpyridinium tosylate is prepared by adding 18.6 g (0.1 mol.) of paratoluen sulphonate methyl ester to 9.7 g (0.1 mol.) of 2-fluoropyridine, heating the resultant mixture for about 20 minutes at 120° C. and cooling the heated mixture to yield 25 g of crystalline 2-fluoro-1-methylpyridinium tosylate (95%). This crystalline starting material is subsequently washed with ether and then dried.

Herkunft & Nachweise