Formamide → HCID 14456868, Verbindung

HRID 1903012Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1903012
[CH3:1][O:2][C:3]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:4]=1[CH2:5][N:6]1[CH:9]([CH2:10]I)[CH2:8][C:7]1=[O:12].[CH:19]([NH2:21])=O.[C-]#N.[Na+]>>[C:19]([CH2:10][CH:9]1[N:6]([CH2:5][C:4]2[CH:13]=[CH:14][C:15]([O:17][CH3:18])=[CH:16][C:3]=2[O:2][CH3:1])[C:7](=[O:12])[CH2:8]1)#[N:21]

Komponenten

4

Edukt 3

HCID 713FormamideHCID 8929Sodium CyanideHCID 14456867HCID 14456867, Verbindung

Produkt 1

HCID 14456868HCID 14456868, VerbindungAusbeute 70 %

Versuchsvorschrift

A solution of 1.2 g. (3.3 mmoles) of 1-(2,4-dimethoxybenzyl)-4-(iodomethyl)-2-azetidinone prepared according to Example 13 in 5 ml. ofddimethyl formamide is stirred with 0.35 g. (7 mmoles) of sodium cyanide for 48 hours, at room temperature. The solution is then poured onto 30 ml. of water and extracted with five 20-ml. portions of ether. The ethereal solution is dried with magnesium sulfate, decolored with activated carbon, filtered and the filtrate is evaporated in vacuo. 0.6 g. (70%) of the named compound are obtained.

Aufarbeitung

  1. customat room temperature
  2. additionThe solution is then poured onto 30 ml
  3. extractionof water and extracted with five 20-ml
  4. dry with materialThe ethereal solution is dried with magnesium sulfate
  5. filtrationfiltered
  6. customthe filtrate is evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-1b7ff7b5be72475fb29a4d64ec6d74b3
Quelldatensatz
uspto-grants-1984_03
Patentnummer
US04435322

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