Hydrochloric Acid → HCID 568802, Verbindung

HRID 1903015Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1903015
[C:1]1([N:7]2[C:10](=[O:11])[CH2:9][CH:8]2[C:12](OCC)=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.P([O-])([O-])(O)=O.[Na+].[Na+]>CO>[C:1]1([N:7]2[CH:8]([CH2:12][OH:13])[CH2:9][C:10]2=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 24203Sodium Phosphate, DibasicHCID 12479106HCID 12479106, Verbindung

Produkt 1

HCID 568802HCID 568802, VerbindungAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a dilution of 106.5 g. (0.486 moles) of ethyl 1-phenyl-4-oxo-2-azetidine-carboxylate prepared according to Example 24 in 700 ml. of methanol 18.74 g. (0.493 moles) of sodium tetrahydrido-borate(III) are added with outer cooling with ice water and stirring. The mixture is acidified with dilute hydrochloric acid and it is then neutralized with disodium hydrogenphosphate. Methanol is distilled off in vacuo. 65 g. (76%) of the named compound are obtained, melting at 100° to 102° C. (ethyl acetate/petroleum ether).

Aufarbeitung

  1. distillationMethanol is distilled off in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7156552f74684ac7bda19e085ce9e4ce
Quelldatensatz
uspto-grants-1984_03
Patentnummer
US04435322

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