2-Phenoxy-4-(4-formylpiperazino)pyrimidine → 2-Phenoxy-4-piperazinopyrimidine

HRID 1903086

Reaktionsgleichung

Reaktionsgleichung von HRID 1903086
[O:1]([C:8]1[N:13]=[C:12]([N:14]2[CH2:19][CH2:18][N:17](C=O)[CH2:16][CH2:15]2)[CH:11]=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.Cl>[O:1]([C:8]1[N:13]=[C:12]([N:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[CH:11]=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 1

HCID 138695712-Phenoxy-4-(4-formylpiperazino)pyrimidine

Produkt 1

HCID 138695632-Phenoxy-4-piperazinopyrimidineAusbeute 64 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittel

Versuchsvorschrift

2-Phenoxy-4-(4-formylpiperazino)pyrimidine (2.6 g) in methanol (27 ml) and 2 N hydrochloric acid (6.9 ml) was left at room temperature for 24 hours and then heated on a steam bath for 30 minutes. The solvent was evaporated in vacuo and the residue re-crystallized twice from isopropanol to give 2-phenoxy-4-piperazinopyrimidine (1.5 g) characterized spectroscopically, and used directly.

Aufarbeitung

  1. temperatureheated on a steam bath for 30 minutes
  2. customThe solvent was evaporated in vacuo
  3. customthe residue re-crystallized twice from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-dc8b28cf533f46818e4d50a65d641ddf
Quelldatensatz
uspto-grants-1984_03
Patentnummer
US04435401

Verknüpfte Notizen

Wird geladen…