Ethanolamine → 1-(2-Hydroxyethyl)-3-phenylurea

HRID 1903289

Reaktionsgleichung

Reaktionsgleichung von HRID 1903289
[CH2:1]([CH2:3][NH2:4])[OH:2].[SH2]=N.[C:7]1([NH:13][C:14](C2C=CC=CC=2C(O)=O)=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>CC(C)=O>[C:7]1([NH:13][C:14]([NH:4][CH2:3][CH2:1][OH:2])=[O:15])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 700EthanolamineHCID 178514671HCID 178514671, Verbindung

Produkt 1

HCID 773521-(2-Hydroxyethyl)-3-phenylureaAusbeute 26,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel2×

Versuchsvorschrift

A solution of 0.65 g ethanolamine with 5 ml aceton was added dropwise to a suspension of 1.5 g phenylcarbamoyl-benzoic acid sulfimide with 10 ml aceton, under stirring. The reaction mixture was stirred for a further 30 minutes at ambient temperature, evaporated in vacuo, the residue was triturated with 20 ml water, and the obtained solid product was filtered, dried and recrystallized. There was obtained 0.25 g 1-phenyl-3-(2-hydroxyethyl)-urea, melting at 120°-122° C.

Aufarbeitung

  1. stirringThe reaction mixture was stirred for a further 30 minutes at ambient temperature
  2. customevaporated in vacuo
  3. customthe residue was triturated with 20 ml water
  4. filtrationthe obtained solid product was filtered
  5. customdried
  6. customrecrystallized

Quellen und Nachweise

ORD-Eintrag
ord-6a4bc0185b8a4f68ba06f1ee91d1b5f7
Quelldatensatz
uspto-grants-1984_03
Patentnummer
US04435567

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