Ammonia → 2-Hydroxybenzonitrile

HRID 1903397

Reaktionsgleichung

Reaktionsgleichung von HRID 1903397
P([O-])([O-])([O-])=O.[B+3].[C:7]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])(=[O:15])[C:8]1[C:9](=[CH:11][CH:12]=[CH:13][CH:14]=1)[OH:10].[NH3:25]>>[OH:10][C:9]1[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=1[C:7]#[N:25].[C:7]([O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])(=[O:15])[C:8]1[C:9](=[CH:11][CH:12]=[CH:13][CH:14]=1)[OH:10]

Komponenten

5

Edukt 3

HCID 222Ammonia2×HCID 62624Benzoic acid, 2-hydroxy-, octyl ester2×HCID 178527087HCID 178527087, Verbindung

Produkt 2

HCID 119072-HydroxybenzonitrileHCID 62624Benzoic acid, 2-hydroxy-, octyl ester

Versuchsvorschrift

A reaction tube having an inside diameter of 5 cm was filled with 293 g of a supported catalyst composed of 3.75% by weight of boron phosphate (P2O5 /B2O3 mole ratio=1) deposited on an alumina carrier spherical alumina carrier having a pore diameter of about 1 micron. Octyl salicylate and ammonia were introduced into the reaction tube at a rate of 108.9 g/hr and 148 g/hr, respectively, and reacted in the vapor phase at 415° C. The mole ratio of ammonia to octyl salicylate in the gaseous mixture was 20:1, and the contact time was 11 seconds. When the reaction was continued for 8 hours, 375.3 g of o-hydroxybenzonitrile was obtained from 871.2 g of octyl salicylate. The yield was 90.5% by weight. Gas-chromatographic analysis showed that only 2.6% by weight of phenol was formed as a by-product.

Aufarbeitung

  1. customA reaction tube having
  2. customrespectively, and reacted in the vapor phase at 415° C
  3. waitWhen the reaction was continued for 8 hours

Quellen und Nachweise

ORD-Eintrag
ord-b7e5700f146d42b0bb13c96cb1405f98
Quelldatensatz
uspto-grants-1984_03
Patentnummer
US04436670

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