Methoxyacetic Acid → 2-Chloroethyl 2-(methoxyacetyl)-2-(2,6-dimethylphenyl)-hydrazinecarboxylate

HRID 1903406

Reaktionsgleichung

Reaktionsgleichung von HRID 1903406
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][NH:10][C:11]([O:13][CH2:14][CH2:15][Cl:16])=[O:12].[CH3:17][O:18][CH2:19][C:20](Cl)=[O:21].COCC(O)=O.S(Cl)(Cl)=O>C1(C)C(C)=CC=CC=1>[CH3:17][O:18][CH2:19][C:20]([N:9]([C:3]1[C:4]([CH3:8])=[CH:5][CH:6]=[CH:7][C:2]=1[CH3:1])[NH:10][C:11]([O:13][CH2:14][CH2:15][Cl:16])=[O:12])=[O:21]

Komponenten

6

Edukt 4

HCID 12251Methoxyacetic AcidHCID 24386Thionyl ChlorideHCID 96623Methoxyacetyl chlorideHCID 130364932-Chloroethyl 2-(2,6-dimethylphenyl)-hydrazinecarboxylate

Produkt 1

HCID 204544942-Chloroethyl 2-(methoxyacetyl)-2-(2,6-dimethylphenyl)-hydrazinecarboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel3×

Versuchsvorschrift

200 g (0.825 mol) 2-Chloroethyl 2-(2,6-dimethylphenyl)-hydrazinecarboxylate in 500 ml xylene are warmed to 80°, and added to a warm (80°) solution of 2-methoxyacetylchloride in 250 ml xylene, prepared in situ by treating 73.5 g (0.826 mol) 2-methoxyacetic acid in 250 ml xylene with 107.1 g (0.9 mol) thionyl chloride at 80° for 2 hours. The mixture is heated for 30 minutes at 80°, then worked up as described in Example 1a.

Aufarbeitung

  1. additionadded to
  2. customprepared in situ
  3. temperatureThe mixture is heated for 30 minutes at 80°

Quellen und Nachweise

ORD-Eintrag
ord-d24ce35884d44744a92e4dc82268ba91
Quelldatensatz
uspto-grants-1984_03
Patentnummer
US04436744

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