L-Phenylalanine → N-[N-(3-hexadecanoyloxyoctadecanoyl)glycyl]-L-phenylalanine

HRID 1903548

Reaktionsgleichung

Reaktionsgleichung von HRID 1903548
[C:1]([O:18][CH:19]([CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH2:20][C:21]([NH:23][CH2:24][C:25]([OH:27])=O)=[O:22])(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[NH2:43][C@H:44]([C:52]([OH:54])=[O:53])[CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1>>[C:1]([O:18][CH:19]([CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])[CH2:20][C:21]([NH:23][CH2:24][C:25]([NH:43][C@H:44]([C:52]([OH:54])=[O:53])[CH2:45][C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1)=[O:27])=[O:22])(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Komponenten

3

Edukt 2

HCID 6140L-PhenylalanineHCID 20216775N-[3-(Hexadecanoyloxy)octadecanoyl]glycine

Produkt 1

HCID 54114728N-[N-(3-hexadecanoyloxyoctadecanoyl)glycyl]-L-phenylalanineAusbeute 64,8 %

Versuchsvorschrift

Starting from N-(3-hexadecanoyloxyoctadecanoyl)glycine (2.6 g) prepared by the method described in Example 27 and L-phenylalanine (1.65 g), N-[N-(3-hexadecanoyloxyoctadecanoyl)glycyl]-L-phenylalanine (2.1 g) was obtained as powders according to a similar manner to that of Example 29.

Aufarbeitung

  1. customprepared by the method

Quellen und Nachweise

ORD-Eintrag
ord-80dc53e49f054c9da5bde262f37aca5a
Quelldatensatz
uspto-grants-1984_03
Patentnummer
US04436726

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