Sodium 1-oxidopyridin-1-ium-2-thiolate → 2-[1-(2-Chloro-6-fluorophenyl)ethylthio]pyridine 1-oxide

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

2-chloro-6-fluoro-alpha-methylbenzyl chloride (46.2, 0.24 mol is dissolved in ethanol (120 Ml) and warmed to 75° C. A 40 percent solution of sodium omadine (98.1 g, 0.26 mol) is added dropwise over a period of 30 minutes maintaining a reaction temperature of 75° C. throughout. Once the addition is complete, the reaction mixture is kept at 75° C. for 2 hours and then stirred at room temperature for 16 hours. Thereafter the mixture is quenched in ice-water and crude product is filtered off. After recrystallization with ethyl acetate pure title product (27.7 g, 40.8%) is obtained; Melting Point 142°-144° C.

Herkunft & Nachweise