Ethyl 4-isothiocyanatobenzoate → HCID 13770053, Verbindung

HRID 1904221

Reaktionsgleichung

Reaktionsgleichung von HRID 1904221
[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([N:12]=[C:13]=[S:14])=[CH:8][CH:7]=1)=[O:5])[CH3:2].[NH2:15][CH2:16][CH2:17][N:18]1[C:22]([CH3:23])=[CH:21][CH:20]=[C:19]1[CH3:24]>COCCOC>[CH3:24][C:19]1[N:18]([CH2:17][CH2:16][NH:15][C:13]([NH:12][C:9]2[CH:10]=[CH:11][C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])=[CH:7][CH:8]=2)=[S:14])[C:22]([CH3:23])=[CH:21][CH:20]=1

Komponenten

4

Edukt 2

HCID 71003Ethyl 4-isothiocyanatobenzoateHCID 13770050HCID 13770050, Verbindung

Produkt 1

HCID 13770053HCID 13770053, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 80711,2-DimethoxyethaneLösungsmittel2×

Versuchsvorschrift

8.3 g (0.04 mol) of 4-ethoxy carbonylphenyl isothiocyanate in 20 ml of ethylene glycol dimethyl ether are added dropwise at room temperature to 5.5 g (0.04 mol) of 1-(2-aminoethyl)-2,5-dimethylpyrrole in 20 ml of ethylene glycol dimethyl ether. The precipitated product is filtered off with suction and recrystallized from methanol. Yield: 5.1 g (37% of theory) Melting point: 155°-156° C. Elemental analysis: C18H23N3O2S (345.47) calculated: C 62.6 H 6.7 N 12.2 0. 9.3 S 9.3 found: C 62.0 H 6.7 N 11.6 0 10.0 S 9.2

Aufarbeitung

  1. filtrationThe precipitated product is filtered off with suction
  2. customrecrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-c2218106b72f405db961502ee182a182
Quelldatensatz
uspto-grants-1989_06
Patentnummer
US04837225

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