Ammonia → 1-(4-Aminophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione

HRID 1904789Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1904789
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:14]([OH:16])=O)[CH2:10][CH:9]2[C:11](O)=[O:12])=[CH:4][CH:3]=1.[NH3:17]>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]23[CH2:10][CH:9]2[C:11](=[O:12])[NH:17][C:14]3=[O:16])=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 200380431-(4-Aminophenyl)-1,2-cyclopropanedicarboxylic acid

Produkt 1

HCID 140689341-(4-Aminophenyl)-3-azabicyclo[3.1.0]hexane-2,4-dione

Versuchsvorschrift

In a glass bomb tube, 2.3 g of 1-(4-aminophenyl)-1,2-cyclopropanedicarboxylic acid are stirred in 80 ml of approx. 1N methanolic ammonia solution for 7 days at 100° C. The reaction mixture is evaporated to dryness and the residue is chromatographed over silica gel with hexane/ethyl acetate (4:6). Recrystallisation from ethanol affords white crystals of the title compound, which is identical with the title compound of Example 1.

Aufarbeitung

  1. customThe reaction mixture is evaporated to dryness
  2. customthe residue is chromatographed over silica gel with hexane/ethyl acetate (4:6)
  3. customRecrystallisation from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-6909bc20c31c4a9f8a89c4819f518c19
Quelldatensatz
uspto-grants-1989_06
Patentnummer
US04839379

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