Pyridine → 5'-Chloro-4'-(2-(2,4-di-tert-pentylphenoxy)butyrylamino)-2'-hydroxybenzanilide

HRID 1904887

Reaktionsgleichung

Reaktionsgleichung von HRID 1904887
[C:1]([NH:9][C:10]1[CH:15]=[C:14]([Cl:16])[C:13]([NH2:17])=[CH:12][C:11]=1[OH:18])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:19]([C:24]1[CH:36]=[C:35]([C:37]([CH2:40][CH3:41])([CH3:39])[CH3:38])[CH:34]=[CH:33][C:25]=1[O:26][CH:27]([CH2:31][CH3:32])[C:28](Cl)=[O:29])([CH2:22][CH3:23])([CH3:21])[CH3:20].N1C=CC=CC=1>C(OCC)(=O)C>[C:1]([NH:9][C:10]1[CH:15]=[C:14]([Cl:16])[C:13]([NH:17][C:28](=[O:29])[CH:27]([O:26][C:25]2[CH:33]=[CH:34][C:35]([C:37]([CH2:40][CH3:41])([CH3:39])[CH3:38])=[CH:36][C:24]=2[C:19]([CH2:22][CH3:23])([CH3:21])[CH3:20])[CH2:31][CH3:32])=[CH:12][C:11]=1[OH:18])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 78779Benzamide, N-(4-amino-5-chloro-2-hydroxyphenyl)-HCID 1703932-(2,4-Bis(1,1-dimethylpropyl)phenoxy)butyryl chloride

Produkt 1

HCID 5711085'-Chloro-4'-(2-(2,4-di-tert-pentylphenoxy)butyrylamino)-2'-hydroxybenzanilide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

In 100 of ethyl acetate was dissolved 15 g (57×10-3 mole) of 2-benzamido-4-chloro-5-aminophenol, and then 21 g of 2-(2,4-di-t-amylphenoxy)butanoic acid chloride and 5 g of pyridine were added thereto and the mixture was stirred at room temperature for 3 hours. After the reaction, a solvent was distilled off, and the residue was separated and purified through column chromatography and recrystallized from n-hexane to obtain the title compound. Yield: 14.1 g, FD-Mass: 564, melting point: 190° to 191° C.

Aufarbeitung

  1. customAfter the reaction
  2. distillationa solvent was distilled off
  3. customthe residue was separated
  4. custompurified through column chromatography
  5. customrecrystallized from n-hexane

Quellen und Nachweise

ORD-Eintrag
ord-3f3b9b169a564527b7c42f85df29503a
Quelldatensatz
uspto-grants-1989_06
Patentnummer
US04840883

Verknüpfte Notizen

Wird geladen…