5'-Chloro-4'-(2-(2,4-di-tert-pentylphenoxy)butyrylamino)-2'-hydroxybenzanilide → 2-Nitro-3-{2-(2,4-di-t-amylphenoxy)butanamido}-4-chloro-6-benzamidophenol

Beteiligte Stoffe

Reaktionsschritte

In 100 ml of acetic acid and 100 ml of dimethylformamide was dissolved 20 g (35×10-3 mole) of 2-benzamido-4-chloro-5-{2-(2,4-di-t-amylphenoxy)butanamido}phenol. To the solution was added dropwise slowly a solution of 2.7 g of sodium nitrite dissolved in 5 ml of a distilled water at room temperature, and then the mixture was stirred for 2 hours. The reaction mixture was poured into ice-cold water, and precipitated yellow solids were collected by filtration and washed with water. Yield: 21 g.

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