3-(Chloromethyl)-5-methyl-1,2,4-oxadiazole → CH-13584

HRID 1904904

Reaktionsgleichung

[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:11])[NH:4][C:3]1=[O:12].[Na].Cl[CH2:15][C:16]1[N:20]=[C:19]([CH3:21])[O:18][N:17]=1>CN(C)C=O>[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][N:7]([CH2:15][C:16]3[N:20]=[C:19]([CH3:21])[O:18][N:17]=3)[C:6]=2[C:5](=[O:11])[NH:4][C:3]1=[O:12]

Komponenten

Reaktionsbedingungen

Temperatur: 100 °C

Versuchsvorschrift

A mixture of 3.76 g of (20 millimoles) of 3-methylxanthine-sodium, 100 ml of dimethyl formamide and 2.60 g (19.6 millimoles) of 3-chloromethyl-5-methyl-1,2,4-oxadiazole is stirred at 100° C. for one hour and a half. The hot reaction mixture is filtered and to the filtrate 50 ml of methanol are added. Thus 3.65 g of 3,7-dihydro-3-methyl-7-([5-methyl-1,2,4-oxadiazole-3-yl]-methyl)-1H-purine-2,6-dione are obtained, m.p.: 262°-264° C. Yield: 69%.

Aufarbeitung

filtrationThe hot reaction mixture is filtered and to the filtrate 50 ml of methanol
additionare added

Quellen und Nachweise

ORD-Eintrag: ord-28789e223b2a40099c9f59ef8492b21e
Quelldatensatz: uspto-grants-1989_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04840949

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