6-[4-(2-t-butoxycarbonylamino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone → 6-[4-(2-amino-2-methylpropyl amino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone

HRID 1905416Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1905416
C(OC([NH:8][C:9]([CH3:27])([CH3:26])[CH2:10][NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:19]([CH3:25])[CH2:20][C:21](=[O:24])[NH:22][N:23]=2)=[CH:14][CH:13]=1)=O)(C)(C)C.C(OCC)(=O)C.Cl>C(OCC)(=O)C>[NH2:8][C:9]([CH3:26])([CH3:27])[CH2:10][NH:11][C:12]1[CH:13]=[CH:14][C:15]([C:18]2[CH:19]([CH3:25])[CH2:20][C:21](=[O:24])[NH:22][N:23]=2)=[CH:16][CH:17]=1

Komponenten

4

Edukt 2

HCID 108332506-[4-(2-t-butoxycarbonylamino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinoneHCID 21866389Hydrogen chloride-ethyl acetate

Produkt 1

HCID 106123876-[4-(2-amino-2-methylpropyl amino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinoneAusbeute 75,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

The 6-[4-(2-t-butoxycarbonylamino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone (3.74 g) obtained in (1-c) above was dissolved in ethyl acetate (10 ml), and 15% hydrogen chloride-ethyl acetate solution (40 ml) was added. The mixture was stirred for 2 hours, and the solvent was evaporated under reduced pressure. The residue was dissolved in water, made alkaline with sodium carbonate, and extracted with chloroform. The extract was dried over MgSO4, and the solvent was evaporated to give 6-[4-(2-amino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone (2.06 g).

Aufarbeitung

  1. customthe solvent was evaporated under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with chloroform
  4. dry with materialThe extract was dried over MgSO4
  5. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-1da59c6e06b340ceb817b9d8b21d183b
Quelldatensatz
uspto-grants-1989_06
Patentnummer
US04843072

Notizen zur Reaktion

Wird geladen…