Methyl iodide → 4-[N-(4-Chloro-benzyl)-methylamino]-cyclohexanol

HRID 1905434

Reaktionsgleichung

Reaktionsgleichung von HRID 1905434
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][NH:7][CH:8]2[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[C:17](=O)([O-])[O-].[K+].[K+].CI>CN(C)C=O>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]([CH3:17])[CH:8]2[CH2:9][CH2:10][CH:11]([OH:14])[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 136706584-(4-Chloro-benzylamino)-cyclohexanol

Produkt 1

HCID 136706604-[N-(4-Chloro-benzyl)-methylamino]-cyclohexanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

7.2 g (30 mMol) of 4-[N-(4-chloro-benzyl)-amino]-cyclohexanol are dissolved in 30 ml of dimethyl-formamide, and after the addition of 2.2 g (16 mMol) of potassium carbonate, 4.26 g (30 mMol) of methyliodide are added dropwise. When the slightly exothermic reaction has ended, the mixture is concentrated by evaporation, mixed with water and extracted with chloroform. The concentrated extracts are chromatographed on silica gel to purify them (eluant; methylene chloride/methanol=20/1).

Aufarbeitung

  1. additionare added dropwise
  2. customWhen the slightly exothermic reaction
  3. concentrationthe mixture is concentrated by evaporation
  4. additionmixed with water
  5. extractionextracted with chloroform
  6. customThe concentrated extracts are chromatographed on silica gel
  7. customto purify them (eluant; methylene chloride/methanol=20/1)

Quellen und Nachweise

ORD-Eintrag
ord-ed43c080daa14d59b7b57eb815a4f62a
Quelldatensatz
uspto-grants-1989_06
Patentnummer
US04843086

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