Dimethylcarbamoyl Chloride → 3-Methyl-1-dimethylcarbamoyloxypyridinium chloride
Reaktionsgleichung
[CH3:1][C:2]1[CH:3]=[N+:4]([O-:8])[CH:5]=[CH:6][CH:7]=1.[CH3:9][N:10]([CH3:14])[C:11]([Cl:13])=[O:12]>>[Cl-:13].[CH3:1][C:2]1[CH:3]=[N+:4]([O:8][C:11](=[O:12])[N:10]([CH3:14])[CH3:9])[CH:5]=[CH:6][CH:7]=1Komponenten
3
Versuchsvorschrift
Also, Fife et al., cited hereabove and Heterocycles 22:93-96(1984), reported the reaction of 3-methylpyridine-1-oxide with dimethyl-carbamoyl chloride to give 3-methyl-1-dimethylcarbamoyloxypyridinium chloride. Reaction of this pyridinium salt with potassium cyanide in water gave 3-methyl-2-cyanopyridine (89%) and the 6-isomer (11%).
Quellen und Nachweise
- ORD-Eintrag
- ord-0ef46d27beeb4da4ad834a52dd0556e3
- Quelldatensatz
- uspto-grants-1989_06
- Patentnummer
- US04843163
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