4,6-Dichloro-5-nitro-2-phenylpyrimidine → 4,6-Dichloro-2-phenylpyrimidin-5-amine

HRID 1905842

Reaktionsgleichung

Reaktionsgleichung von HRID 1905842
[Cl:1][C:2]1[C:7]([N+:8]([O-])=O)=[C:6]([Cl:11])[N:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:3]=1>CCOCC.C([O-])(=O)C.[Ni]>[NH2:8][C:7]1[C:2]([Cl:1])=[N:3][C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:5][C:6]=1[Cl:11]

Komponenten

4

Edukt 1

HCID 1006444,6-Dichloro-5-nitro-2-phenylpyrimidine

Produkt 1

HCID 7366734,6-Dichloro-2-phenylpyrimidin-5-amineAusbeute 72,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 21226428Ether acetateLösungsmittel

Versuchsvorschrift

27.0 g of 4,6-dichloro-5-nitro-2-phenylpyrimidine are hydrogenated in ether acetate at room temperature by treatment with Raney nickel. The catalyst is afterwards separated and the reaction solution is concentrated by evaporation. Crystallisation of the residue from petroleum ether then yields 17.4 g of 5-amino-4,6-dichloro-2-phenylpyrimidine, m.p. 143°-144° C. (compound No. 1).

Aufarbeitung

  1. customThe catalyst is afterwards separated
  2. concentrationthe reaction solution is concentrated by evaporation
  3. customCrystallisation of the residue from petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-0585826f0ec546e39554c0e3decd9b03
Quelldatensatz
uspto-grants-1987_03
Patentnummer
US04648896

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