Boron trifluoride etherate → N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane

HRID 1906122Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1906122
[C:1]([N:11]1[CH2:13][CH:12]1[CH3:14])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].[C:15]([CH:19]([C:21]([CH3:24])([CH3:23])[CH3:22])[OH:20])([CH3:18])([CH3:17])[CH3:16].B(F)(F)F.CCOCC.C([O-])(O)=O.[Na+]>C(Cl)Cl>[C:1]([NH:11][CH:12]([CH3:14])[CH2:13][O:20][CH:19]([C:21]([CH3:24])([CH3:23])[CH3:22])[C:15]([CH3:18])([CH3:17])[CH3:16])([O:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)=[O:2]

Komponenten

6

Edukt 4

HCID 8000Boron trifluoride etherateHCID 1397902,2,4,4-Tetramethylpentan-3-olHCID 516892Sodium BicarbonateHCID 21895246Benzyl 2-methylaziridine-1-carboxylate

Produkt 1

HCID 20201216N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

N-Cbz-2-Methyl aziridine and di-t-butylmethanol are dissolved in CH2Cl2 at 0° C. under argon. Boron trifluoride etherate is added and the flask is stirred overnight. The contents are poured into saturated NaHCO3 and are extracted with ethyl acetate. The organic layer is dried over MgSO4 and evaporated to yield N-Cbz-2-amino 1-[di-(t-butyl)methoxy]propane.

Aufarbeitung

  1. extractionare extracted with ethyl acetate
  2. dry with materialThe organic layer is dried over MgSO4
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-5c78ce2e5b55455498bffcf9eca2cf69
Quelldatensatz
uspto-grants-1987_03
Patentnummer
US04650688

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