1-Bromopropane → HCID 13823145, Verbindung
Reaktionsgleichung
[CH3:1][NH:2][C:3]1[S:4][CH:5]=[C:6]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)[N:7]=1.Br[CH2:15][CH2:16][CH3:17]>>[CH3:1][NH:2][C:3]1[S:4][CH:5]=[C:6]([C:8]2[CH2:9][N:10]([CH2:15][CH2:16][CH3:17])[CH2:11][CH2:12][CH:13]=2)[N:7]=1Komponenten
3
Versuchsvorschrift
The procedure described in Example 1 was repeated, using the N-methyl-4-(3-pyridinyl)-2-thiazolamine prepared in Example 14 and an excess of 1-bromopropane as the reactants. The title compound was purified by column chromatography (65% yield) and converted to its HCl salt by the procedure of Example 2. The resulting salt (mp 138° C.) contained 1.25 molecules of HCl and one molecule of water.
Aufarbeitung
- customThe title compound was purified by column chromatography (65% yield)
Quellen und Nachweise
- ORD-Eintrag
- ord-287302bec2034127b7f7c11ba9431164
- Quelldatensatz
- uspto-grants-1987_03
- Patentnummer
- US04650805
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