Ammonia → 4h-Quinolizin-4-one-3-carboxamide

HRID 1906206Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1906206
[CH:1]1[CH:2]=[C:3]([C:12]([OH:14])=O)[C:4](=[O:11])[N:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2.C(N1C=CN=C1)([N:17]1C=CN=C1)=O.N>CN(C)C=O>[CH:1]1[CH:2]=[C:3]([C:12]([NH2:17])=[O:14])[C:4](=[O:11])[N:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 682631,1'-CarbonyldiimidazoleHCID 15632080HCID 15632080, Verbindung

Produkt 1

HCID 119605794h-Quinolizin-4-one-3-carboxamideAusbeute 85,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a suspension of 4H-quinolizin-4-one-3-carboxylic acid (2.27 g) in dry N,N-dimethylformamide (22.7 ml) was added 1,1'-carbonyldiimidazole (2.92 g). The resulting suspension was heated to 100° C. and kept for 30 minutes. After cooling to room temperature the resulting solution was treated with dry ammonia and stirred for 20 minutes. The crystals separated was collected by filtration and washed with water to give 4H-quinolizin-4-one-3-carboxamide (1.94 g).

Aufarbeitung

  1. temperatureAfter cooling to room temperature the resulting solution
  2. customThe crystals separated
  3. filtrationwas collected by filtration
  4. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-d477bd4169604fa886ebe36528287943
Quelldatensatz
uspto-grants-1987_03
Patentnummer
US04650804

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