Ammonia → HCID 13885367, Verbindung

HRID 1906346Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1906346
[N:1]1([S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[S:14](F)(=[O:16])=[O:15])(=[O:7])=[O:6])[CH2:4][CH2:3][CH2:2]1.[NH3:18]>C1COCC1>[N:1]1([S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[S:14]([NH2:18])(=[O:16])=[O:15])(=[O:7])=[O:6])[CH2:4][CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 222Ammonia2×HCID 13885366HCID 13885366, Verbindung

Produkt 1

HCID 13885367HCID 13885367, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

In a 1-l flask was placed 9.8 g. of 2-(azetidin-1-ylsulfonyl)benzenesulfonyl fluoride and 500 ml of THF. Then 9 ml of ammonia was added and the mixture was refluxed for two days. Four 25 ml portions of liquid ammonia were then added to the refluxing solution over a 48 hour period. The reaction mixture was concentrated and the residue chromatographed on silica gel (dichloroethane). The desired product was collected to give 4.9 g of a solid m.p. 121°-123° C.

Aufarbeitung

  1. customIn a 1-l flask was placed
  2. temperaturethe mixture was refluxed for two days
  3. concentrationThe reaction mixture was concentrated
  4. customthe residue chromatographed on silica gel (dichloroethane)
  5. customThe desired product was collected

Quellen und Nachweise

ORD-Eintrag
ord-b4661df4c4b34930b3f74a1af7f87b47
Quelldatensatz
uspto-grants-1987_03
Patentnummer
US04652304

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