Triethylamine → HCID 13799782, Verbindung

HRID 1906394Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1906394
[Cl:1][CH2:2][CH2:3][CH2:4][S:5](Cl)(=[O:7])=[O:6].[NH2:9][C:10]([CH3:14])([CH3:13])[C:11]#[N:12].C(N(CC)CC)C>C(Cl)Cl>[CH3:13][C:10]([NH:9][S:5]([CH2:4][CH2:3][CH2:2][Cl:1])(=[O:7])=[O:6])([CH3:14])[C:11]#[N:12]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 154103-Chloropropanesulphonyl chlorideHCID 880222-Amino-2-methylpropionitrile

Produkt 1

HCID 13799782HCID 13799782, VerbindungAusbeute 88,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a stirred mixture of 9.90 g (0.05 mole) 3-chloropropane sulfonyl chloride and 4.71 g (0.056 mole) 2-amino-2-methyl-propionitrile in 100 ml methylene chloride at 0° C., 5.66 g (0.056 mole) triethylamine as a 10% solution in methylene chloride was added very slowly. The reaction mixture was allowed to stir overnight in the gradually melting ice bath. The reaction mixture was washed three times with 50 ml water. The organic layer was dried over calcium sulfate and evaporated to give 9.90 g of the above-identified product as a brown oil.

Aufarbeitung

  1. washThe reaction mixture was washed three times with 50 ml water
  2. dry with materialThe organic layer was dried over calcium sulfate
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-713009c3297d4ce6b18085c91542da66
Quelldatensatz
uspto-grants-1987_03
Patentnummer
US04652556

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