HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
N-Methylhydrazinecarbothioamide → N-Ethyl-N-[3-[3-(methylamino)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]phenyl]-propanamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | N-Methylhydrazinecarbothioamide | HCID 2723853 | — |
| Edukt | N-ethyl-N-[3-(6-chloro-3-pyridazinyl)phenyl]propanamide | HCID 14280299 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | N-Ethyl-N-[3-[3-(methylamino)-1,2,4-triazolo[4,3-b]pyridazin-6-yl]phenyl]-propanamide | HCID 15595697 | 8,9% |
Reaktionsschritte
A solution of 5.0 g N-ethyl-N[3-(6-chloro-3-pyridazinyl)phenyl]propanamide and 3.8 g of 4-methylthiosemicarbazide in 200 ml ethanol was refluxed for 18 hours. The mixture was then treated and the product chromatographed as described for Example 70. Recrystallization of the product from acetone-hexane afforded 0.5 g orange crystals, mp 172°-173° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04654343 |
| Quelldatensatz | uspto-grants-1987_03 |
| ORD ID | ord-ec4bcb30d4f44ff39f9105a6e72a6dff |
| Quellennotiz | uspto-grants-1987_03 |