1-(2,6-Xylyl)piperazine → 1-[(6-Fluoro-3-methoxyquinoxalin-2-yl)aminocarbonyl]-4-(2,6-dimethylphenyl)piperazine

HRID 1907540

Reaktionsgleichung

Reaktionsgleichung von HRID 1907540
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[CH3:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH3:27])[C:22]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:31]1[CH2:32][CH2:33][N:28]([C:22]3[C:23]([CH3:27])=[CH:24][CH:25]=[CH:26][C:21]=3[CH3:20])[CH2:29][CH2:30]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Komponenten

3

Edukt 2

HCID 705381-(2,6-Xylyl)piperazineHCID 69243333ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate

Produkt 1

HCID 692436011-[(6-Fluoro-3-methoxyquinoxalin-2-yl)aminocarbonyl]-4-(2,6-dimethylphenyl)piperazineAusbeute 76 %

Versuchsvorschrift

Ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate and 1-(2,6-dimethylphenyl)piperazine were reacted by the same way with the example 85 to obtain the titled compound (yield, 76%). 1H NMR (300 MHz, CDCl3): δ 2.36 (s, 6H), 3.18-3.21 (m, 4H), 3.69-3.72 (m, 4H), 4.15 (s, 3H), 6.97-7.04 (m, 3H), 7.22-7.42 (m, 4H), 7.82-7.87 (m, 1H).

Quellen und Nachweise

ORD-Eintrag
ord-c73cf12bbcf54f8ab0bfae429ec9e244
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08598173B2

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