1-(m-Tolyl)piperazine → 1-[(2,6,7-Trimethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3-methylphenyl)piperazine

HRID 1907648

Reaktionsgleichung

Reaktionsgleichung von HRID 1907648
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:18])OCC)=[N:11][C:10]2[C:5](=[CH:6][C:7]([O:21][CH3:22])=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1.[CH3:23][C:24]1[CH:25]=[C:26]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[CH:27]=[CH:28][CH:29]=1>>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:33]2[CH2:34][CH2:35][N:30]([C:26]3[CH:27]=[CH:28][CH:29]=[C:24]([CH3:23])[CH:25]=3)[CH2:31][CH2:32]2)=[O:18])=[N:11][C:10]2[C:5](=[CH:6][C:7]([O:21][CH3:22])=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1

Komponenten

3

Edukt 2

HCID 831111-(m-Tolyl)piperazineHCID 69244380HCID 69244380, Verbindung

Produkt 1

HCID 692443591-[(2,6,7-Trimethoxyquinoxalin-3-yl)aminocarbonyl]-4-(3-methylphenyl)piperazineAusbeute 56 %

Versuchsvorschrift

Ethyl N-(2,6,7-trimethoxyquinoxalin-3-yl)carbamate and 1-(3-methylphenyl) piperazine were reacted by the same way with the example 190 to obtain the titled compound (yield, 56%) H NMR (300 MHz, CDCl3) δ 2.34 (s, 3H), 3.25-3.30 (m, 4H), 3.76-3.80 (m, 4H), 3.98 (s, 3H), 4.02 (s, 3H), 4.16 (s, 3H), 6.74-6.78 (m, 3H), 7.14-7.26 (m, 4H).

Quellen und Nachweise

ORD-Eintrag
ord-3869dfe93f754597a8acf94f143d3dd6
Quelldatensatz
uspto-grants-2013_12
Patentnummer
US08598173B2

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