HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diphenylsilane → 4-(4-Bromo-3-fluorobenzyl)morpholine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diphenylsilane | HCID 69888 | — |
| Edukt | (4-Bromo-3-fluorophenyl)(morpholin-4-yl)methanone | HCID 48474115 | — |
| Katalysator | Carbonyltris(triphenylphosphine)rhodium(I)hydride | HCID 53249357 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 4-(4-Bromo-3-fluorobenzyl)morpholine | HCID 53417818 | — |
Reaktionsschritte
A 250 ml flask was charged with (4-bromo-3-fluorophenyl)(morpholino)methanone (4.569 g, 15.86 mmol) and dissolved in 16 mL of THF. Diphenylsilane (6.2 ml, 33.4 mmol) was added followed by carbonyltris(triphenylphosphine)rhodium(I)hydride (100 mg, 0.109 mmol) and the reaction stirred at room temperature for 20 hours.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08598169B2 |
| Quelldatensatz | uspto-grants-2013_12 |
| ORD ID | ord-7f048c54528c4de8b280552f6360c4a3 |
| Quellennotiz | uspto-grants-2013_12 |